How long does the chuck roast need to cook?
Slow-smoke or braise the chuck roast chunks until fork-tender, typically 6–8 hours on low heat or until fully shredded with minimal resistance.
Can I make Mississippi pot roast sandwiches ahead of time?
Yes. Shred and braise the roast up to 2 days ahead, store in an airtight container, and reheat gently before assembling and toasting the rolls.
What can I substitute for pepperoncini peppers?
Banana peppers or drained pickled jalapeños work as alternatives, though they will shift the flavor profile slightly toward heat rather than tangy brine.
Can I use a different cut of beef?
Brisket or beef chuck shoulder work well; avoid lean cuts like sirloin, which won't achieve the same tender, shredded texture in slow cooking.
How do I make the au jus?
Strain the braising liquid after shredding the roast, skim excess fat, and simmer with beef broth and pan drippings until flavorful; serve warm for dipping.